Information about Huntington's disease
Philly Cure HD, Inc. (Huntington's Disease)
·Symptoms of Huntington's disease are treatable. Unawareness can be a frustrating symptom for family members, but HSG member and neurologist Martha Nance and HSG…
Last updated 2 years ago
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Symptoms of HD and Support for these Symtpoms
About Huntington’s Disease
Huntingtin mutation - The HTT gene is located on chromosome 4 and encodes a protein called huntingtin. The gene contains a sequence of three nucleotides (the basic units of DNA), cytosine-adenine-guanine (CAG), that is repeated several times. This so-called trinucleotide repeat can vary in length. If a person has 40 CAG repeats or more in one copy of the HTT gene, s/he will develop HD within a normal lifespan – that is, in mid-adult life.
About Huntington’s Disease
The determinants of age at onset for Huntington's disease are complex. In general, the higher the number of CAG repeats, the earlier the onset of symptoms. However, for any given CAG repeat number, the variability in age at onset may be up to 30 years. This is probably due to the effects of genes other than HTT (so-called genetic modifiers), and to environmental factors such as lifestyle and diet. Taking this altogether, it’s very difficult to accurately predict ….
Huntington's disease symptoms often eventually include difficulty in communicating. The 24 Hour Non Speech Challenge means voluntarily not talking for 24 hours. During that time, only alternative means of communication, such as writing, symbols, gestures, applications, etc. can be used. By attempting this challenge, you will help the general public understand the impact that a communication handicap has on our daily lives and the obstacles that a person who cannot talk faces every day.
A highly visual infographic that captures the nature of repetitive symptoms and their impact on the lives of people living with dementia. Repetitive symptoms are often misunderstood and create frustration and exhaustion for clients and their family/professional caregivers. It is important to remember that people with dementia cannot control their symptoms. #DementiaCaregiving
Executive Function Primer (Part 1)
Executive function, which is impaired in Huntington's disease, is a broad term that refers to the cognitive processes that help us regulate, control and manage our thoughts and actions. It includes planning, working memory, attention, problem solving, verbal reasoning, inhibition, cognitive flexibility, initiation of actions and monitoring of actions. #huntingtonsdisease
Cardiac symptom overlaps between Huntington's disease and other neuro-cardio diseases. Symptoms listed are those evident in mouse models of HD at CNS pre-symptomatic or symptomatic stages. AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; BSMA, bulbar spinal muscular atrophy; FA, Friedreich’s ataxia; HD, Huntington’s disease; PD, Parkinson’s disease; TS, Timothy syndrome.
Five Facts About: Huntington's Disease [Infographic]
Rare Disease Report - Five Facts About: Huntington's Disease. Huntington's disease (HD) is a life-threatening neurodegenerative disease caused by an unbalanced cytosine-adenine-guanine (CAG) repeat expansion in the Huntingtin gene (HTT), which leads to the production of the toxic huntingtin (mHTT) protein. The mutant mHTT protein progressively destroys neurons in the brain, leading to a rapid decline in neuromuscular and cognitive abilities.
Huntington's Disease: A Tongue Twister in Your Genes?
Huntington's Disease: A Tongue Twister in Your Genes? - YouTube Huntington's Disease is a rare genetic disorder that causes brain damage over time. Currently, there is no cure. However, scientists are working hard to find one! How? One way is to look at how our cells naturally fight against the disease.
Stages of Huntington's Disease – HOPES Huntington's Disease Information
Stages-of-HD People with Huntington’s disease (HD) follow a path of disease progression once symptoms begin. While patients can remain highly functional in the first years of the disease, independence gives way as symptoms get worse. This article discusses the ways in which HD symptoms change from one stage to the next, the degree to which …